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Press Kit and Other Publications Related to Immunization and Vaccine- Preventable Disease

2004, 412 pp.
ISBN 92 75 11596 6 4
Code: SP 596
Price: US$ 62.00/
US$ 46.00 in Latin America and the Caribbean
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Vaccines: Preventing Disease and Protecting Health is now available in electronic format!


Note: please read a corrigendum for chapter "Oral Vaccines Derived from Transgenic Plants"



Vaccines:

Preventing Disease and Protecting Health

Vaccines: Preventing Disease and Protecting Health celebrates the various ways vaccines have played a role in improving the health of the world’s populations. In early sections, the book relates successful efforts to fight disease with vaccines, including the eradication of polio from the Americas and the potential contribution of new measles vaccine formulations to reducing measles mortality worldwide. It also looks at the challenges posed in using vaccines to cope with emerging and re-emerging diseases, such as HIV/AIDS and bioterrorism.

In subsequent sections, the authors examine innovative efforts underway to test the efficacy of vaccines against diseases such as meningococcal infection in Africa, Haemophilus influenza type b, varicella, and hepatitis A, and look at efforts to develop a new generation of vaccines against cholera and typhoid, shigella, and Helicobacter pylori. The advances in influenza vaccine development and Hepatitis C are also presented.

The book includes sections on the quest for vaccines against tuberculosis, HIV/AIDS, dengue, malaria, and hookworm. New concepts for vaccine development, adjuvants and delivery systems such as maternal immunization, DNA vaccines, and oral vaccines derived from transgenic plants are also discussed.

Later sections deal with the use of vaccines against potential bioterrorism attacks, with a particular emphasis on smallpox and anthrax. Regulatory and safety issues related to vaccines are also presented from the various perspectives of the public sector, the pharmaceutical industry, and the vaccine consumer.

The final chapter highlights the ongoing challenges of vaccine development, disease prevention, internal and external financing and sustainability of immunization programs, and the impact of health sector reform on these issues.

Dr. Ciro A. de Quadros, the book’s technical editor, also contributed significant chapters to the book. The roster of authors reads like a "Who's Who" in public health and in vaccine development and use. These men and women are the best scientists in their fields. They are breaking new ground in vaccines and immunization programs, bringing the promise of health to the world's populations.


Preface (30.5 KB)

Introduction (33.4 KB)

Authors and Affiliation (39.5 KB)

SETTING THE STAGE

Vaccines and the Challenge of Emerging and Re-Emerging Diseases: From HIV/AIDS to Bioterrorism
Anthony S. Fauci


A Century of Vaccines and Immunization in the Americas (107.8 KB)
Ciro A. de Quadros


PART I. THE PRESENT

Polio: Present Status and Post-Eradication Policies
Daniel Tarantola


Potential for Circulation of Vaccine-derived Polioviruses
Philip Minor


Is Global Measles Eradication Feasible?
Ciro A. de Quadros


New Measles Vaccine Formulations and Delivery Systems and their Potential Contribution to Reducing Measles Mortality Worldwide
Maria Teresa Aguado and Ana-Maria Henao-Restrepo


The Burden of Congenital Rubella Syndrome
Louis Z. Cooper


Accelerated Control of Rubella and Prevention of Congenital Rubella Syndrome: Experiences in the Americas
Gina Tambini, Carlos Castillo-Solórzano, Mónica Brana, and Ciro A. de Quadros


The Challenge of Yellow Fever
Thomas P. Monath


PART II. THE CUTTING EDGE

Haemophilus Influenzae Type B: The Burden in Asia
John Clemens and Paul Kilgore


Development of a Live Varicella Vaccine: Current Status and Prospects
Michiaki Takahashi


Hepatitis A Vaccines
Stanley M. Lemon


Conjugate Meningococcal Vaccines for Africa
F. Marc LaForce


The Efficacy and Effectiveness of Pneumococcal Conjugate Vaccines
Keith P. Klugman


PART III. THE FUTURE

Rotavirus Vaccines
Roger Glass, Umesh Parashar, Joseph Bresee, Jon Gentsch, Reina Turcios, and Baoming Jiang


Typhoid Fever and Cholera Vaccines
Myron M. Levine

Progress in Shigella Vaccine Development
Karen L. Kotloff


Human Papillomavirus
Ian H. Frazer


Success in Vaccinating against Helicobacter pylori
Steven J. Czinn


Hepatitis C
Stephen Coates, Qui-Lim Choo, George Kuo, Kevin Crawford, Christine Dong, Mark Wininger, Amy Weiner, Sergio Abrignani, and Michael Houghton


Advances in Influenza Vaccine Development
John Treanor


Vaccine Prospects for Respiratory Syncytial Virus
Peter F. Wright

PART IV. THE QUEST

A New Generation of Tuberculosis Vaccines
Michael J. Brennan


A New Polio Vaccine?
Jeronimo Cello, Nadia De Jesus, Konstantin Chumakov, Jiang Yin, Aniko V. Paul, Matthias Gromeier, and Eckard Wimmer


The Quest for a Preventive Vaccine Against HIV/AIDS
José Esparza


Dengue Vaccines
David W. Vaughn


Progress Toward a Malaria Vaccine
Regina Rabinovich

Hookworm in the Americas: Progress in the Development of an Anti-hookworm Vaccine
Peter J. Hotez


PART V. NEW CONCEPTS FOR VACCINE DEVELOPMENT, ADJUVANTS, AND DELIVERY SYSTEMS

Mucosal Vaccines to Induce Cellular Immunity Against HIV and Other Viral Infections
Jay A. Berzofsky and Igor M. Belyakov

Maternal Immunization
W. Paul Glezen


DNA Vaccines: A Review
Margaret A. Liu


Oral Vaccines Derived from Transgenic Plants
Charles J. Arntzen, Richard T. Mahoney, Hugh S. Mason, and Dwayne D. Kirk

New Adjuvants
Nathalie Garçon and Moncef Slauoi


The PowderJect Particle-mediated Epidermal Delivery of DNA Vaccines: A New Technology
John Beadle


VI. VACCINES AND BIOTERRORISM

Smallpox Vaccine
Donald A. Henderson


Anthrax
Arthur M. Friedlander


Vaccines Against Viral Hemorrhagic Fevers
Clarence J. Peters


VII. REGULATORY AND SAFETY ISSUES

The Public Sector Perspective
Manfred Haase


The Industry Perspective
Luis Barreto

The Consumers’ Perspective
David Salisbury


VIII. VACCINES, PREVENTION, AND PUBLIC HEALTH

The Role of Prevention in Health and Public Health: Challenges for the Future
Carlyle Guerra de Macedo


External Finance of Immunization Programs: Time for a Change in Paradigm?
Dean T. Jamison


A Vision for the Future Sustainability of National Financing of Immunization Programs
Julio Frenk Mora, Roberto Tapia Conyer, and José Ignacio Santos


The Role of Multilateral Financing Institutions in Supporting Immunization Programs
Alfredo Solari


The Potential Impact of Health Reform on Immunization Programs
Fernando Muñoz, Oscar Arteaga, Sergio Muñoz, and Mario I. Tarride


Perspectives for the Elimination/Eradication of Diseases with Vaccines
Walter R. Dowdle


EPILOGUE: CONFERENCE ON VACCINES, PREVENTION, AND PUBLIC HEALTH: A VISION FOR THE FUTURE

Welcoming Remarks
George A.O. Alleyne


Summation
Donald A. Henderson


Meeting Agenda


List of Participants



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