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Practical Guide for in vivo Antimalarial Drug-Efficacy Studies in the Americas (RAVREDA-AMI, revised version, October 2003)
Resistance of Plasmodium falciparum to antimalarial drugs is one of the most serious challenges facing national malaria control programs in the Americas. While in vivo drug-efficacy studies do not require sophisticated technology, they are not simple to conduct correctly. They require a well-trained and experienced clinical and laboratory team that closely follows the study protocol. The purpose of this guide, which is based on recent experiences with antimalarial drug efficacy studies in South America, was to complement to the WHO guidelines and standardized protocols. It is hoped that this guide, together with the generic protocols, will contribute to the successful implementation of in vivo studies and a surveillance system for antimalarial drug resistance in the Americas.  (3/Oct/2003)
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